Primary graft dysfunction after liver transplantation: From pathogenesis to prevention
نویسندگان
چکیده
منابع مشابه
Primary Graft Dysfunction After Lung Transplantation.
Primary graft dysfunction is a form of acute injury after lung transplantation that is associated with significant short- and long-term morbidity and mortality. Multiple mechanisms contribute to the pathogenesis of primary graft dysfunction, including ischemia reperfusion injury, epithelial cell death, endothelial cell dysfunction, innate immune activation, oxidative stress, and release of infl...
متن کاملInitial Poor Graft Dysfunction and Primary Graft Non-Function After Orthotopic Liver Transplantation
Orthotopic liver transplantation (OLT) has become the effective treatment for end-stage liver diseases. Since the 1980s, the successful rate of liver transplantation has increased with the improvement of operative methods and the use of University of Wisconsin (UW) solution. Nevertheless, liver procurement and implantation are inevitably associated with allograft damage. Lack of donor liver hin...
متن کاملLong Term Impact of Primary Graft Dysfunction after Lung Transplantation
According to the International Society for Heart and Lung Transplantation (ISHLT) Registry, graft failure accounted for 24.7% of deaths within 30 days of transplantation among adult lung recipients between 1992 and 2012 [1]. Although important details distinguishing different causes of early graft failure may be missing from the Registry data, it is likely that primary graft dysfunction (PGD) i...
متن کاملGraft calcifications and dysfunction following liver transplantation
BACKGROUND The molecular events, following ischemia and reperfusion (I/R) of the liver during transplantation are largely unknown. There is evidence that apoptotic and necrotic events may take place, and occasionally result in primary graft dysfunction. We herein report two cases, where significant I/R injury correlated with the development of liver calcification and primary liver dysfunction. ...
متن کاملPost-reperfusion Liver Biopsy and Its Value in Predicting Mortality and Graft Dysfunction after Liver Transplantation
Background: The outcome of the patients after liver transplant is complex and to characterize the risk for complications is not always easy. In this context, the hepatic post-reperfusion biopsy is capable of portraying alterations of prognostic importance. Aim: To compare the results of liver transplantation, correlating the different histologic features of the hepatic post-reperfusion biops...
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ژورنال
عنوان ژورنال: Liver Transplantation and Surgery
سال: 1997
ISSN: 1074-3022
DOI: 10.1002/lt.500030206